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dc.contributor.authorLu, Uen_US
dc.contributor.authorHu, BCPen_US
dc.contributor.authorShih, YCen_US
dc.contributor.authorWu, CYen_US
dc.contributor.authorYang, YSen_US
dc.date.accessioned2014-12-08T15:39:10Z-
dc.date.available2014-12-08T15:39:10Z-
dc.date.issued2004-05-15en_US
dc.identifier.issn0956-5663en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.bios.2003.11.025en_US
dc.identifier.urihttp://hdl.handle.net/11536/26772-
dc.description.abstractWe designed a complementary metal oxide semiconductor (CMOS) chip with accompanied accessories as a system for the detections and quantifications of biochemical luminescence. This is the first of such instruments that has been reported. The semiconductor chip was manufactured through a 0.25 mum CMOS standard process. A current mirror was designed in integrated circuit (IC) to amplify the signal current that was induced by chemiluminescence. Horseradish peroxidase (HRP)-luminol-H2O2 system was used as an example to constitute a useful platform for coupling to chemiluminescence reactions which produce H2O2. Glucose-glucose oxidase (GOD) reaction was coupled with HRP-luminol-H2O2 reaction to demonstrate the ability of the novel CMOS base instrument for quantifying the biological luminescence of a variety of valuable clinical assays. Our results illustrated that the combination of the specifically designed CMOS IC and commercially available electronic devices established a simple and useful bioanalytical tool. (C) 2003 Elsevier B.V. All rights reserved.en_US
dc.language.isoen_USen_US
dc.subjectCMOSen_US
dc.subjectIC designen_US
dc.subjectbioluminescenceen_US
dc.subjectenzyme chipen_US
dc.subjectbiochemical analysisen_US
dc.titleThe design of a novel complementary metal oxide semiconductor detection system for biochemical luminescenceen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.bios.2003.11.025en_US
dc.identifier.journalBIOSENSORS & BIOELECTRONICSen_US
dc.citation.volume19en_US
dc.citation.issue10en_US
dc.citation.spage1185en_US
dc.citation.epage1191en_US
dc.contributor.department生物科技學系zh_TW
dc.contributor.department電子工程學系及電子研究所zh_TW
dc.contributor.departmentDepartment of Biological Science and Technologyen_US
dc.contributor.departmentDepartment of Electronics Engineering and Institute of Electronicsen_US
dc.identifier.wosnumberWOS:000220702600007-
dc.citation.woscount18-
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