標題: A CMOS-Based Phototransistor for High-Sensitivity Biochemical Detection Using Absorption Photometry
作者: Chang, Yu-Wei
Tai, Yu-Ting
Huang, Yang-Tung
Yang, Yuh-Shyong
電子工程學系及電子研究所
Department of Electronics Engineering and Institute of Electronics
關鍵字: Biomedical transducers;medical diagnosis;photodetectors;phototransistors
公開日期: 2008
摘要: This paper proposes a high-sensitivity biosensing system on the basis of absorption photometry and a phototransistor. Manufactured in a standard 0.35-mu m CMOS technology, the phototransistor exhibits a responsivity higher than 1000 A/W for 650-nm light. The TMB/H(2)O(2)/HRP method is chosen as a useful platform to determine the amount of various interesting targets. For the biochemical detection, a sample volume of only 10 mu l is required to be dropped on the slide above the phototransistor. Experimental results demonstrate that a high sensitivity of 2.5 mu A/pM is achieved, and the minimum HRP concentration successfully detected is 2.7 pM. This detection limit is three orders of magnitude better than that of a reported silicon biosensor.
URI: http://hdl.handle.net/11536/31342
ISBN: 978-1-4244-2176-3
期刊: PROCEEDINGS OF THE THIRD INTERNATIONAL CONFERENCE ON SENSING TECHNOLOGY
起始頁: 82
結束頁: 85
Appears in Collections:Conferences Paper