標題: Design and fabrication of a microplatform for the proximity effect study of localized ELF-EMF on the growth of in vitro HeLa and PC-12 cells
作者: Chen, Y. C.
Chen, C. C.
Tu, W.
Cheng, Y. T.
Tseng, F. G.
電子工程學系及電子研究所
Department of Electronics Engineering and Institute of Electronics
公開日期: 1-Dec-2010
摘要: This paper presents a platform technology with experimental results that show the scientists and biologists a way to rapidly investigate and analyze the biological effects of localized extremely low frequency (ELF) electromagnetic field (EMF) on living cells. The proximity effect of the localized ELF-EMF on living cells is revealed using the bio-compatible microplatform on which an on-glass inductive coil array, the source of the localized ELF-EMF in micro scale, is designed, fabricated and operated with a field strength of 1.2 +/- 0.1 mT at 60 Hz for cell culturing study. After a 72 h ELF-EMF exposure, HeLa (human cervical cancer) and PC-12 (rat pheochromocytoma) cells exhibit about 18.4% and 12.9% cell proliferation rate reduction, respectively. Furthermore, according to the presented dynamic model, the reduction of the proliferation can be attributed to the interference of signal transduction processes due to the tangential currents induced around the cells.
URI: http://dx.doi.org/10.1088/0960-1317/20/12/125023
http://hdl.handle.net/11536/31894
ISSN: 0960-1317
DOI: 10.1088/0960-1317/20/12/125023
期刊: JOURNAL OF MICROMECHANICS AND MICROENGINEERING
Volume: 20
Issue: 12
起始頁: 
結束頁: 
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