研究對合成熔融，線性和角雜環可溶性小分子庫的支持，新的癌症治療

Abstract

一種新型的離子液體的支持下，合成的協議已經發展走向合成四氫-β-咔氧和硫乙內酰脲類似物，二氫喹唑啉和四氫喹唑啉類似物的使用重點微波照射高純度和優良的產量。對於我們第一次開發出合成四氫-β-咔氧和硫乙內酰脲類似物在環境良性媒體對離子液體的支持。

A novel ionic liquid supported, synthetic protocol has been developed toward the synthesis of tetrahydro-β-carboline oxo and thio hydantoin analogs, dihydro-quinazolines and tetrahydro-quinazolines analogue by the use of focused microwave irradiation with high purity and excellent yields. For the first time we have developed the synthesis of tetrahydro-β-carboline oxo and thio hydantoin analogs in environmentally benign media on ionic liquid support. We have also developed the synthesis of dihydro-quinazolines and tetrahydro-quinazolines analogue on ionic liquid support under mild condition with minimum synthetic step. In a study aimed at developing a novel concise approach to the benzimidazole-pyrrolo[1,2-a]quinoxaline and benzimidazole-pyrrolo[1,2-a]quinoxalinone core of medicinal interest, a SNAr/Pictet-Spengler reaction and partial nitro group reduction/SN2 reaction has been identified that gives the direct access to the target compound on soluble polymer support under focused microwave irradiation. For the first time we have introduced pyrrole and pyrrole carboxylate moiety into the aromatic system by SNAr reaction. Further subsequent pictet-spengler cyclisation, partial nitro group reduction and SN2 reaction has been developed for the medicinally important core of benzimidazole-pyrrolo[1,2-a]quinoxaline and benzimidazole-pyrrolo[1,2-a]quinoxalinone analogs.