标题: 可相容高工作电压且具有负载适应性之抑制癫痫发作电流刺激器设计
Design of High-Voltage-Tolerant Stimulus Driver to Suppress Epileptic Seizure with Adaptive Loading Consideration in Low-Voltage Process
作者: 李易儒
Li, Yi-Ju
柯明道
Ker, Ming-Dou
电子研究所
关键字: 癫痫;刺激器;Epilepsy;Stimulus Driver
公开日期: 2010
摘要: 电刺激技术已是一种常见的医疗方式,例如功能性电刺激 (functional electrical stimulation, FET) 与治疗性电刺激 (therapeutic electrical stimulation, TES)。透过电流讯号流过患者的待刺激部位,可使患者恢复部分身体的机能。而随着积体电路制程的微缩化,整合智慧型仿生系统于单晶片的目标已变得可行,此系统单晶片可植入动物体,以对患部进行电刺激。对植入性晶片而言,设计时的主要考量为安全性、可靠度与功率消耗。
本文所提出的电路为可相容高工作电压且具有负载适应性之抑制癫痫发作电流刺激器。由于在刺激器输出刺激电流时,输出端会有将近十伏特的高压产生,为了承受输出端的高压,过去的刺激器电路都是使用高压制程来实作,而本刺激器电路为了与智慧型仿生系统中的其他电路做单晶片整合,因此必须使用低压制程来实作。本刺激器透过电路设计的技巧,使其能以低压制程元件来承受高压,而电晶体不会面临电性过压的情形。此外,当待刺激部位的阻抗在设计的范围内变化时,电流刺激器亦能提供稳定的刺激电流。最后,本设计已由动物实验获得验证,刺激器可有效地抑制老鼠的癫痫病症发作。
The treatment of using a stimulus driver has been investigated and verified. By stimulating the nerves may recover the patient’s physical functions. It can be applied to functional electrical stimulation and therapeutic electrical stimulation. As the CMOS process developed, using an implantable device to provide stimulus current can be accomplished. The main considerations of designing an implantable device are safety, reliability, and power consumption.
The proposed stimulus driver is utilized to suppress epileptic seizure. Due to the loading impedance is hundreds kΩ and the stimulus current is tens μA, the voltage at the output of stimulus driver is ~10 V. Conventional works are fabricated in high-voltage process in order to sustain the high voltage at output of stimulus driver. To be integrated with other circuits into SoC, this work is implemented in low-voltage process. By designing the structure, this work fabricated in 0.18-μm 1.8-V/3.3-V CMOS process is able to sustain high voltage (~10 V) without gate-oxide overstress. It can provide stimulus current ~40 μA as the loading impedance varies from 100 kΩ to 250 kΩ. The function of this work has been verified in the animal test experiment.
URI: http://140.113.39.130/cdrfb3/record/nctu/#GT079811659
http://hdl.handle.net/11536/46825
显示于类别:Thesis


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