合成2-去氧α醣苷鍵的立體選擇性及連續性醣基化方法開發

標題:	合成2-去氧α醣苷鍵的立體選擇性及連續性醣基化方法開發 Development of Stereoselective and Iterative Glycosylation Method for Synthesis of 2-deoxy-α-glycosides
作者:	陳俊翰 Chen, Jiun-Han 蒙國光 Mong, Kwok-Kong 應用化學系碩博士班
關鍵字:	2-去氧醣;alpha選擇性;連續醣基化;預活化醣基化;寡醣合成;2-deoxy suger;alpha selectivity;iterative glycosylation;pre-activation glycosylation;synthesize oligosaccharide
公開日期:	2012
摘要:	我們將二甲基甲醯胺調控醣基化策略運用在2-去氧硫醣予體上，成功與多個帶有相同離去基團的赤道位硫醣受體及2-去氧硫醣受體耦合出alpha醣苷鍵。利用NMR-study順利觀測到中間體glucosyl imidinium triflate。並運用此法成功合成出含有三個alpha醣苷鍵的四醣。 We applied DMF-modulated glycosylation to 2-deoxy-thioglycosyl donor to construct alpha glycoside with wide equatorial-OH thioglycosyl and 2-deoxy-thioglycosyl accepter, which contain the same leaving group. Used NMR-study to observe intermediate, glucosyl imidinium triflate successfully. Then finished the synthesis of tatrasaccharide which contain 3 alpha glycosidic bonds.
URI:	http://140.113.39.130/cdrfb3/record/nctu/#GT079925544 http://hdl.handle.net/11536/49881
Appears in Collections:	Thesis