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dc.contributor.author廖政二en_US
dc.contributor.authorCheng-Erh Liaoen_US
dc.contributor.author吳獻仁en_US
dc.contributor.author鍾文聖en_US
dc.contributor.authorHsin-Jen Wuen_US
dc.contributor.authorWen-Sheng Chungen_US
dc.date.accessioned2014-12-12T02:07:54Z-
dc.date.available2014-12-12T02:07:54Z-
dc.date.issued2003en_US
dc.identifier.urihttp://140.113.39.130/cdrfb3/record/nctu/#GT009125552en_US
dc.identifier.urihttp://hdl.handle.net/11536/55090-
dc.description.abstract在液相反應中,我們以benzene sulfinic acid sodium salt為起始物,經歷三個反應步驟,以三烷基鋁為切割試劑,成功的合成出1-(4-Bromophenyl)-2-(4-vinylphenyl)propane與1-(4-Bromophenyl)-2-(4-vinylphenyl)butane;接著,在實驗室中我們成功的製備以砜基為連結元件之樹脂,且應用此砜基樹酯為固相有機合成之載體,並開發三烷基鋁為固相有機合成之切割試劑,順利的合成出21個衍生物的化合物庫。 另外,我們也以砜基樹酯,引進環狀雙烷基取代,並應用三烷基鋁為切割試劑,成功的合成出兩個四環之化合物3-methyl-3-(4-vinylphenyl)cyclobutan-1-ol和3-ethyl-3-(4-vinylphenyl)-cyclobutan-1-ol。zh_TW
dc.description.abstractUsing sulfinate functionalized resin as a solid support, we have developed a new cleavage reagent, Al(CH3)3 and Al(CH2CH3)3, In monoalkylation successfully synthesized 1-(4-Bromophenyl)-2-(4-vinylphenyl) propane and 1-(4-Bromophenyl)-2-(4-vinylphenyl) butane; In dialkylation successfully synthesized 3-methyl-3-(4-vinylphenyl) cyclobutan-1-ol and 3-ethyl-3-(4-vinylphenyl) cyclobutan-1-ol First of all, benzene sulfinic acid sodium salt was used as starting material in liquid phase experiment. Through three reaction steps, we obtained compound 4 and 5, which demonstrated that cleavage reagent can be successfully Then, we successfully prepared resin 6 which has sulfone linker. Using resin 6 as solid support in SPOS, similar reaction conditions in liquid phase and Al(CH3)3 and Al(CH2CH3)3 as cleavage reagent, we obtained the products form solid support. Application of SPOS technique, we synthesized compounds which includes 4、5、10、11、13、14、16、17、19、21、22、25、26、28、29、31、32、34、35、37、38、41、42.en_US
dc.language.isozh_TWen_US
dc.subject固相有機合成zh_TW
dc.subject三烷基鋁zh_TW
dc.subject切割試劑zh_TW
dc.subjectSolid-Phase Organic Synthesisen_US
dc.subjectCleavage Reagentsen_US
dc.subjectTrialkylalumiumen_US
dc.title三烷基鋁作為砜基之切割試劑的固相有機合成研究zh_TW
dc.titleTrialkylalumium as Cleavage Reagents for Sulfone Linker in Solid-Phase Organic Synthesisen_US
dc.typeThesisen_US
dc.contributor.department應用化學系碩博士班zh_TW
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