聚乳酸成形蜂巢結構薄膜與電漿輔助改質表面研究

Abstract

蜂巢狀結構的支架備製，使用可生物降解性的聚乳酸(Polylactide)為主要原料，在濕度的環境法 (breath figure method)製造蜂巢狀結構(簡稱honeycomb pattern)之材料，改善細胞在平坦無結構之薄膜上的增生速度，再利用以氮氣為主參入適當比例的氧氣產生的低溫常壓電漿，來作為表面改質技術，利用電漿的特性可把官能基植入表面以利於細胞貼附。主要探討honeycomb pattern 成形孔洞的參數條件和電將處理表面前後表面特性為研究。將利用濕度之氣流量、聚乳酸溶液濃度、濕度溫度等，各種參數的調整來改變honeycomb pattern孔洞的尺寸。藉由高解析度場發射掃描電子顯微鏡來檢測成形孔洞和表面結構的情形，水滴接觸角量測儀測量電將處理表面前後的表面能，結果顯示，honeycomb pattern的孔洞會依實驗參數調整而影響孔洞尺寸，目前可產生均勻性的孔洞尺寸範圍為2~3m，在濕度的環境溫度30℃下成形，在未經過低溫電漿表面處理前 水滴接觸角為80∘以上，電漿處理後降為65±2∘，詳細的結果在文中會有所描述。

Honeycomb-patterned films with polymer were fabricated by a high humidity method and were treated using low temperature plasma. A two-dimensional honeycomb pattern was formed when a polylactide(PLA) solution with surfactant-free was cast on solid surfaces under atmospheric condition with high humidity. The pattern, the pore size, and surface energy were then evaluated by SEM and contact angle. The results showed that the pore size range distributes differently under different operation conditions. Air flow, polymer type, PLA concentration, and humidity were found to be important factors in the formation of honeycomb-structured thin films. The case with a pore size of 2 m shows a great uniformity under 30℃ humidified environment. The water contact angle with 80 degrees on the film surface showed the hydrophobicity of the film surface, which was an important result of the formation of the porous structure. After low-temperature plasma treatment the honeycomb-pattern films, water contact angle decreases to 65o±2. Detailed results are described in the thesis.