Importance of Saccharomyces cerevisiae Oxidosqualene-Lanosterol Cyclase Tyrosine 707 Residue for Chair-Boat Bicyclic Ring Formation and Deprotonation Reactions

doi:10.1021/ol802036c

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DC 欄位	值	語言
dc.contributor.author	Wu, Tung-Kung	en_US
dc.contributor.author	Wang, Tsai-Ting	en_US
dc.contributor.author	Chang, Cheng-Hsiang	en_US
dc.contributor.author	Liu, Yuan-Ting	en_US
dc.contributor.author	Shie, Wen-Shiang	en_US
dc.date.accessioned	2014-12-08T15:10:40Z	-
dc.date.available	2014-12-08T15:10:40Z	-
dc.date.issued	2008-11-06	en_US
dc.identifier.issn	1523-7060	en_US
dc.identifier.uri	http://dx.doi.org/10.1021/ol802036c	en_US
dc.identifier.uri	http://hdl.handle.net/11536/8159	-
dc.description.abstract	A contact mapping strategy was applied to identity putative amino acid residues that influence the oxidosqualene-lanosterol B-ring cyclization reaction. A bicyclic intermediate with two altered deprotonation products, in conjunction with lanosterol, were isolated from the ERG7(Y707X) mutants, indicating that the Tyr707 residue may play a functional role in stabilizing the chair-boat bicyclic C-8 cation and the lanosteryl C-8/C-9 cation intermediates.	en_US
dc.language.iso	en_US	en_US
dc.title	Importance of Saccharomyces cerevisiae Oxidosqualene-Lanosterol Cyclase Tyrosine 707 Residue for Chair-Boat Bicyclic Ring Formation and Deprotonation Reactions	en_US
dc.type	Article	en_US
dc.identifier.doi	10.1021/ol802036c	en_US
dc.identifier.journal	ORGANIC LETTERS	en_US
dc.citation.volume	10	en_US
dc.citation.issue	21	en_US
dc.citation.spage	4959	en_US
dc.citation.epage	4962	en_US
dc.contributor.department	生物科技學系	zh_TW
dc.contributor.department	Department of Biological Science and Technology	en_US
dc.identifier.wosnumber	WOS:000260534500063	-
dc.citation.woscount	14	-
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