標題: Synthesis of structurally diverse benzimidazolyl benzimidazolones by application of soluble polymer support
作者: Chen, Hsia-Yuan
Kulkarni, Manohar V.
Chen, Chih-Hau
Sun, Chung-Ming
應用化學系
Department of Applied Chemistry
公開日期: 30-Jun-2008
摘要: Chemical stability and reactivity of a bifunctional polymer conjugate containing an ortho-amino arylamide linkage have been successfully exploited to achieve a parallel synthesis of methoxycarbonylated head-tail bis-benzimidazoles. Regioselective alkylation of the two nitrogens in the benzimidazolone moiety has been carried out by ipso-fluoro displacement, and N-alkylation to generate two diversities. Cleavage of the polymer support has resulted in two libraries of di- and tri-substituted benzimidazolyl benzimidazolones in high purity and high yield. All reaction steps have been monitored by (1)H NMR on the support directly. (c) 2008 Elsevier Ltd. All rights reserved.
URI: http://dx.doi.org/10.1016/j.tet.2008.04.081
http://hdl.handle.net/11536/8694
ISSN: 0040-4020
DOI: 10.1016/j.tet.2008.04.081
期刊: TETRAHEDRON
Volume: 64
Issue: 27
起始頁: 6387
結束頁: 6394
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