标题: | Microwave Promoted Simple, Efficient and Regioselective Synthesis of Trisubstituted Imidazo[1,2-a]benzimidazoles on Soluble Support |
作者: | Chen, Li-Hsun Hsiao, Ya-Shan Yellol, Gorakh S. Sun, Chung-Ming 应用化学系 Department of Applied Chemistry |
关键字: | microwave-assisted;polymer-supported;amino benzimidazoles;biologically interesting |
公开日期: | 1-三月-2011 |
摘要: | An efficient microwave-assisted and soluble polymer-supported synthesis of medicinally important imidazole-fused benzimidazoles has been developed. The protocol involves the rapid condensation of polymer-bound amino benzimidazoles with various alpha-bromoke-tones and subsequent in, situ intramolecular cyclization under microwave irradiation resulting in a one pot synthesis of imidazole interlacing benzimidazole polymer conjugates. The condensed product was obtained with excellent regioselectivity. The biologically interesting imidazo [1,2-a]benzimidazoles was released from polymer support at ambient temperature. Diversity in the triheterocyclic nucleus was achieved by the different substitutions at its 2, 3, and 9 positions. The new protocol has the advantages of short reaction time, easy workup process, excellent yields, reduced environmental impact, wide substrate scope and convenient procedure. |
URI: | http://dx.doi.org/10.1021/co1000037 http://hdl.handle.net/11536/9182 |
ISSN: | 2156-8952 |
DOI: | 10.1021/co1000037 |
期刊: | ACS COMBINATORIAL SCIENCE |
Volume: | 13 |
Issue: | 2 |
起始页: | 112 |
结束页: | 119 |
显示于类别: | Articles |
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