A Telescoping Synthesis of Chimeric Polyheterocycles through a Piperidine-Mediated Multicomponent Reaction

Abstract

A new piperidine-catalyzed Groebke-Bienayme-Blackburn (GBB) multicomponent reaction of 2-aminobenzimidazoles, methyl 2-formylbenzoate, and isocyanides has been explored. A facile and straightforward postmodification leads to isoquinolinone-embedded imidazo[1,2-a]benzimidazoles. Insight into a plausible mechanism is discussed and supported by X-ray crystal structure analysis.