標題: Glycosylation Chemistry of 3-Deoxy-D-manno-Oct-2-ulosonic Acid (Kdo) Donors
作者: Pradhan, Tapan Kumar
Mong, Kwok Kong Tony
交大名義發表
National Chiao Tung University
公開日期: 1-Apr-2015
摘要: 3-Deoxy-D-manno-Oct-2-ulosonic acid (Kdo)-containing oligosaccharides are a conserved carbohydrate component in lipopolysaccharides ( LPSs) of the outer membrane of Gram-negative bacteria, and they are also present in capsular polysaccharides ( CPSs) of bacteria and plant cells. The association of the bacterial LPS with the pathophysiology of bacterial infection have long been recognized. Structure-pathophysiology studies of bacterial infection need to use pure and homogeneous LPS fragments. Such a requirement can be fulfilled by the synthesis of Kdo glycosides and related Kdo-oligosaccharide conjugates. This article provides an overview of the glycosylation chemistries of the synthesis of Kdo alpha-/beta-glycosides, oligosaccharides with Kdo units such as LPS core oligosaccharides, and lipid A derivatives.
URI: http://dx.doi.org/10.1002/ijch.201400145
http://hdl.handle.net/11536/124697
ISSN: 0021-2148
DOI: 10.1002/ijch.201400145
期刊: ISRAEL JOURNAL OF CHEMISTRY
Volume: 55
Issue: 3-4
起始頁: 285
結束頁: 296
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