標題: | One pot synthesis of oxygenated tri-heterocycles as anti-microbial agents |
作者: | Khan, IA Kulkarni, MV Sun, CM 應用化學系 Department of Applied Chemistry |
關鍵字: | coumarins;tri-heterocycles;antibacterial activity |
公開日期: | 1-Nov-2005 |
摘要: | A one pot synthesis of an array of angularly linked tri-heterocycles with coumarin, benzofuran and furan rings is described. This high yielding synthesis is achieved by the reaction of various 4-bromomethylcoumarins with furyl o-hydroxyphenyl ketones involving benzylic nucleophilic displacement and intramolecular aldolization. All the compounds have been tested in vitro for their anti-microbial activity against Micrococcus aureus, Pseudomonas chinchori, Asperigillus fumigatus and Penicillium wortmanni at 100, 50, and 25 mu g ml(-1) concentrations. Chloro groups in the benzofuran ring enhanced the activity. (c) 2005 Elsevier SAS. All rights reserved. |
URI: | http://dx.doi.org/10.1016/j.ejmech.2005.05.007 http://hdl.handle.net/11536/13095 |
ISSN: | 0223-5234 |
DOI: | 10.1016/j.ejmech.2005.05.007 |
期刊: | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY |
Volume: | 40 |
Issue: | 11 |
起始頁: | 1168 |
結束頁: | 1172 |
Appears in Collections: | Articles |
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