標題: Noninvasive, label-free, three-dimensional imaging of melanoma with confocal photothermal microscopy: Differentiate malignant melanoma from benign tumor tissue
作者: He, Jinping
Wang, Nan
Tsurui, Hiromichi
Kato, Masashi
Iida, Machiko
Kobayashi, Takayoshi
電子物理學系
Department of Electrophysics
公開日期: 22-Jul-2016
摘要: Skin cancer is one of the most common cancers. Melanoma accounts for less than 2% of skin cancer cases but causes a large majority of skin cancer deaths. Early detection of malignant melanoma remains the key factor in saving lives. However, the melanoma diagnosis is still clinically challenging. Here, we developed a confocal photothermal microscope for noninvasive, label-free, three-dimensional imaging of melanoma. The axial resolution of confocal photothermal microscope is similar to 3 times higher than that of commonly used photothermal microscope. Three-dimensional microscopic distribution of melanin in pigmented lesions of mouse skin is obtained directly with this setup. Classic morphometric and fractal analysis of sixteen 3D images (eight for benign melanoma and eight for malignant) showed a capability of pathology of melanoma: melanin density and size become larger during the melanoma growth, and the melanin distribution also becomes more chaotic and unregulated. The results suggested new options for monitoring the melanoma growth and also for the melanoma diagnosis.
URI: http://dx.doi.org/10.1038/srep30209
http://hdl.handle.net/11536/134018
ISSN: 2045-2322
DOI: 10.1038/srep30209
期刊: SCIENTIFIC REPORTS
Volume: 6
起始頁: 0
結束頁: 0
Appears in Collections:Articles


Files in This Item:

  1. c4a15e118f9b6c0933bc1cd091b4848c.pdf

If it is a zip file, please download the file and unzip it, then open index.html in a browser to view the full text content.