標題: Cognitive enhancers associated with decreased risk of injury in patients with dementia: a nationwide cohort study in Taiwan
作者: Chao, Pei-Chun
Chien, Wu-Chien
Chung, Chi-Hsiang
Chu, Ching-Wen
Yeh, Chin-Bin
Huang, San-Yuan
Lu, Ru-Band
Chang, Hsin-An
Kao, Yu-Chen
Yeh, Hui-Wen
Chiang, Wei-Shan
Chou, Yu-Ching
Tzeng, Nian-Sheng
交大名義發表
National Chiao Tung University
關鍵字: dementia;national health insurance research database;cohort study;cognitive enhancers
公開日期: 1-Mar-2018
摘要: This study aimed to investigate the associations among dementia, psychotropic medications and the risk of overall injuries. In this nationwide matched cohort study, a total of 144008 enrolled patients age of 50, with 36002 study subjects who suffered from dementia and 108006 controls matched for sex and age, from the Inpatient Dataset, for the period 2000-2010 in Taiwan were selected from the National Health Insurance Research Database, according to International Classification of Diseases, 9th Revision, Clinical Modification. When adjusting for the confounding factors, a Cox proportional hazards analysis was used to compare the risk of developing psychiatric disorders during the 10 years of follow-up. Of the study subjects, 6701 (18.61%) suffered injury when compared with 20919 (19.37%) in the control group. The Cox regression analysis revealed that the study subjects were more likely to develop an injury (HR: 2.294, 95% CI=2.229 to 2.361, P<0.001) after adjusting for sex, age, monthly income, urbanization level, geographic region, and comorbidities. Psychotropic medications in the subjects with dementia were associated with the risk of injury (adjusted HR=0.217, 95%CI: 0.206 to 0.228, P<0.001). Cognitive enhancers, including acetylcholinesterase inhibitors and memantine, were associated with the risk of injury in the study subjects after being adjusted for all comorbidities and medications (adjusted HR=0.712(95% CI=0.512 to 0.925, P<0.01)). In conclusion, patients who suffered dementia had a higher risk of developing injury, and the cognitive enhancers were associated with the decreased risk of injury.
URI: http://dx.doi.org/10.1136/jim-2017-000595
http://hdl.handle.net/11536/144779
ISSN: 1081-5589
DOI: 10.1136/jim-2017-000595
期刊: JOURNAL OF INVESTIGATIVE MEDICINE
Volume: 66
起始頁: 684
結束頁: 692
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