標題: | Rapid Two-Step Synthesis of Benzimidazo[1 ',2 ':1,5]-pyrrolo[2,3-c]isoquinolines by a Three-Component Coupling Reaction |
作者: | Narhe, Bharat D. Tsai, Min-Huan Sun, Chung-Ming 應用化學系 Department of Applied Chemistry |
關鍵字: | microwave;ionic liquid support;pyrrolo[1,2-a]benzimidazole;benzimidazo[1',2':1,5]pyrrolo[2,3-c]isoquinolines |
公開日期: | 1-八月-2014 |
摘要: | A two-step, three-component coupling reaction on ionic liquid supported 2-cyanomethylbenzimidazoles, methyl 2-formylbenzoate, and isocyanides under microwave activation is explored. Knoevenagel condensation of 2-cyanomethylbenzimidazole with methyl-2-formylbenzoate in the presence of piperidine catalyst is followed by [4 + 1] cycloaddition with an isocyanide in the next step. Consequent intramolecular delta-lactam formation allows rapid construction of novel aza-pentacycles, benzimidazo [1',2':1,5]pyrrolo [2,3-c]isoquinolines. |
URI: | http://dx.doi.org/10.1021/co500049r http://hdl.handle.net/11536/147783 |
ISSN: | 2156-8952 |
DOI: | 10.1021/co500049r |
期刊: | ACS COMBINATORIAL SCIENCE |
Volume: | 16 |
起始頁: | 421 |
結束頁: | 427 |
顯示於類別: | 期刊論文 |