標題: Development of a Multisite, Closed-loop Neuromodulator for the Theranosis of Neural Degenerative Diseases
作者: Chen, Hsin
Chang, Yen-Chung
Yeh, Shih-Rung
Hsieh, Chih-Cheng
Tang, Kea-Tiong
Hsieh, Ping-Hsuan
Liao, Yu-Te
Perumel, Ramesh
Chuang, Ji-Feng
Chang, Ching-Chih
Chen, Yu-Chieh
Chen, Shih-Hsin
Hsieh, Sung-En
Chen, Yen-Peng
Chen, Ye-Ting
Liu, Tzu-Hao
Chang, Yu-Ming
Lai, Wei-Chih
Wu, Chuang-Yi
Chen, Yu-Hsin
Weng, Yi-Chin
交大名義發表
National Chiao Tung University
關鍵字: implantable microsystem;closed-loop control;neuromodulation;multisite;neural disorders
公開日期: 1-Jan-2018
摘要: Stimulating specific brain regions has been found useful for treating neural disorders, such as the Parkinson's disease, epilepsy, depression, etc. However, how electrical stimulation modulates neural activities remains not fully understood. As animal models provide the advantage of recording and stimulating different disease-related regions simultaneously, this paper introduces the latest development of a multisite, closed-loop-controlled microsystem for investigating novel treatments on neural degenerative diseases with freely-moving rats. The algorithms for recognizing pathological neural activities automatically are also developed and realized in hardware, so as to control the stimulation in a closed loop and in real time. The pilot studies on the efficacy of treating the Parkinson's disease with closed-loop-controlled stimulation will be presented and discussed. Finally, the feasibility of modelling and probing how neural dynamics and connectivity are modulated by stimulation will be an important topic for future research.
URI: http://hdl.handle.net/11536/152026
ISBN: 978-1-5386-4218-4
期刊: 2018 IEEE SYMPOSIUM ON VLSI TECHNOLOGY
起始頁: 37
結束頁: 38
Appears in Collections:Conferences Paper