標題: | Development of a Multisite, Closed-loop Neuromodulator for the Theranosis of Neural Degenerative Diseases |
作者: | Chen, Hsin Chang, Yen-Chung Yeh, Shih-Rung Hsieh, Chih-Cheng Tang, Kea-Tiong Hsieh, Ping-Hsuan Liao, Yu-Te Perumel, Ramesh Chuang, Ji-Feng Chang, Ching-Chih Chen, Yu-Chieh Chen, Shih-Hsin Hsieh, Sung-En Chen, Yen-Peng Chen, Ye-Ting Liu, Tzu-Hao Chang, Yu-Ming Lai, Wei-Chih Wu, Chuang-Yi Chen, Yu-Hsin Weng, Yi-Chin 交大名義發表 National Chiao Tung University |
關鍵字: | implantable microsystem;closed-loop control;neuromodulation;multisite;neural disorders |
公開日期: | 1-一月-2018 |
摘要: | Stimulating specific brain regions has been found useful for treating neural disorders, such as the Parkinson's disease, epilepsy, depression, etc. However, how electrical stimulation modulates neural activities remains not fully understood. As animal models provide the advantage of recording and stimulating different disease-related regions simultaneously, this paper introduces the latest development of a multisite, closed-loop-controlled microsystem for investigating novel treatments on neural degenerative diseases with freely-moving rats. The algorithms for recognizing pathological neural activities automatically are also developed and realized in hardware, so as to control the stimulation in a closed loop and in real time. The pilot studies on the efficacy of treating the Parkinson's disease with closed-loop-controlled stimulation will be presented and discussed. Finally, the feasibility of modelling and probing how neural dynamics and connectivity are modulated by stimulation will be an important topic for future research. |
URI: | http://hdl.handle.net/11536/152026 |
ISBN: | 978-1-5386-4218-4 |
期刊: | 2018 IEEE SYMPOSIUM ON VLSI TECHNOLOGY |
起始頁: | 37 |
結束頁: | 38 |
顯示於類別: | 會議論文 |