標題: | The Prognostic Value of Circulating Tumor Cells in Asian Neuroendocrine Tumors |
作者: | Hsieh, Jason Chia-Hsun Chen, Guan-Yu Jhou, David Da-Wei Chou, Wen-Chi Yeh, Chun-Nan Hwang, Tsann-Long Lin, Hung-Chi Chu, Hui-Chun Wang, Hung-Ming Yen, Tzu-Chen Chen, Jen-Shi Wu, Min-Hsien 交大名義發表 生物科技學系 National Chiao Tung University Department of Biological Science and Technology |
公開日期: | 27-Dec-2019 |
摘要: | Circulating tumor cells (CTC) play important roles in various cancers; however, few studies have assessed their clinical utility in neuroendocrine tumors. This study aimed to prospectively evaluate the prognostic value of CTC counts in Asian patients with neuroendocrine tumors before and during anti-cancer therapy. Patients who were diagnosed with unresectable histological neuroendocrine tumors between September 2011 and September 2017 were enrolled. CTC testing was performed before and during anti-cancer therapy using a negative selection protocol. Chromogranin A levels were also assessed. Univariate and multivariate Cox's proportional hazard model with forward LR model was performed to investigate the impact of independent factors on overall survival and progression-free survival. Kaplan-Meier method with log-rank tests were used to determine the difference among different clinicopathological signatures and CTC cutoff. The baseline CTC detection rate was 94.3% (33/35). CTC counts were associated with cancer stages (I-III vs. IV, P = 0.015), liver metastasis (P = 0.026), and neuroendocrine tumor grading (P = 0.03). The median progression-free survival and overall survivals were 12.3 and 30.4 months, respectively. In multivariate Cox regression model, neuroendocrine tumors grading and baseline CTC counts were both independent prognostic factors for progression-free survival (PFS, P = 0.005 and 0.015, respectively) and overall survival (OS, P = 0.018 and 0.023, respectively). In Kaplan-Meier analysis, lower baseline chromogranin A levels were associated with longer PFS (P = 0.024). Baseline CTC counts are associated with the clinicopathologic features of neuroendocrine tumors and are an independent prognostic factor for this malignancy. |
URI: | http://dx.doi.org/10.1038/s41598-019-56539-z http://hdl.handle.net/11536/153761 |
ISSN: | 2045-2322 |
DOI: | 10.1038/s41598-019-56539-z |
期刊: | SCIENTIFIC REPORTS |
Volume: | 9 |
起始頁: | 0 |
結束頁: | 0 |
Appears in Collections: | Articles |