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dc.contributor.authorTsai, Yueh-Chunen_US
dc.contributor.authorWu, Jose Jiun-Shianen_US
dc.contributor.authorLin, Po-Kangen_US
dc.contributor.authorLin, Bo-Jyunen_US
dc.contributor.authorWang, Pin-Shiouen_US
dc.contributor.authorLiu, Ching-Hsiangen_US
dc.contributor.authorWu, Chung-Yuen_US
dc.contributor.authorChiao, Chuan-Chinen_US
dc.date.accessioned2020-07-01T05:22:09Z-
dc.date.available2020-07-01T05:22:09Z-
dc.date.issued2020-02-21en_US
dc.identifier.issn1932-6203en_US
dc.identifier.urihttp://dx.doi.org/10.1371/journal.pone.0228861en_US
dc.identifier.urihttp://hdl.handle.net/11536/154565-
dc.description.abstractA wireless photovoltaic retinal prosthesis is currently being studied with the aim of providing prosthetic vision to patients with retinitis pigmentosa (RP) and age-related macular degeneration (AMD). The major challenge of a photovoltaic device is its limited power efficiency. Our retinal prosthetic design implements a unique divisional power supply scheme (DPSS) system that provides the electrical power generated by all of the solar cells to only a subset of electrodes at any moment in time. The aim of the present study was to systematically characterize the spatiotemporal integration performance of the system under various DPSS conditions using human subjects and a psychophysical approach. A 16x16 pixels LED array controlled by Arduino was used to simulate the output signal of the DPSS design, and human performance under different visual stimulations at various update frequencies was then used to assess the spatiotemporal capability of retinal prostheses. The results showed that the contrast polarity of the image, image brightness, and division number influenced the lower limit of the update frequency of the DPSS system, while, on the other hand, visual angle, ambient light level, and stimulation order did not affect performance significantly. Pattern recognition by visual persistence with spatiotemporal integration of multiple frames of sparse dots is a feasible approach in retinal prosthesis design. These findings provide an insight into how to optimize a photovoltaic retinal prosthesis using a DPSS design with an appropriate update frequency for reliable pattern recognition. This will help the development of a wireless device able to restore vision to RP and AMD patients in the future.en_US
dc.language.isoen_USen_US
dc.titleSpatiotemporal integration of visual stimuli and its relevance to the use of a divisional power supply scheme for retinal prosthesisen_US
dc.typeArticleen_US
dc.identifier.doi10.1371/journal.pone.0228861en_US
dc.identifier.journalPLOS ONEen_US
dc.citation.volume15en_US
dc.citation.issue2en_US
dc.citation.spage0en_US
dc.citation.epage0en_US
dc.contributor.department電子工程學系及電子研究所zh_TW
dc.contributor.department生醫電子轉譯研究中心zh_TW
dc.contributor.departmentDepartment of Electronics Engineering and Institute of Electronicsen_US
dc.contributor.departmentBiomedical Electronics Translational Research Centeren_US
dc.identifier.wosnumberWOS:000535227900032en_US
dc.citation.woscount0en_US
Appears in Collections:Articles