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dc.contributor.authorChen, Chih-Hauen_US
dc.contributor.authorChen, Chan-Yuen_US
dc.contributor.authorLin, Po-Tsungen_US
dc.contributor.authorSun, Chung-Mingen_US
dc.date.accessioned2014-12-08T15:24:22Z-
dc.date.available2014-12-08T15:24:22Z-
dc.date.issued2012-08-01en_US
dc.identifier.issn1381-1991en_US
dc.identifier.urihttp://dx.doi.org/10.1007/s11030-012-9383-0en_US
dc.identifier.urihttp://hdl.handle.net/11536/16916-
dc.description.abstractA novel multicomponent reaction between IL-anchored 2-aminobenzoimidazoles, aldehydes, and electron-deficient dienophiles has been explored. The strategy was utilized to develop a rapid parallel synthesis for novel bis-heterocyclic skeleton of benzimidazole-linked dihydropyrimidine on an ionic liquid support. This multicomponent reaction is compatible with a wide range of substrates and furnishes the new chimeric scaffolds with high purity and excellent yields. Use of the ionic liquid as a soluble support facilitates purification by simple precipitation along with advantages like high loading capacity, homogeneous reaction conditions, and monitoring of the reaction progress by conventional NMR spectroscopy.en_US
dc.language.isoen_USen_US
dc.subjectMulticomponent reactionen_US
dc.subjectMCRen_US
dc.subjectIonic liquid supporten_US
dc.subjectChimeric scaffoldsen_US
dc.subject[1,5]Sigmatropic rearrangementen_US
dc.subjectBenzimidazole-linked dihydropyrimidineen_US
dc.titleNovel ionic liquid supported-multicomponent reaction toward chimeric bis-heterocyclesen_US
dc.typeArticleen_US
dc.identifier.doi10.1007/s11030-012-9383-0en_US
dc.identifier.journalMOLECULAR DIVERSITYen_US
dc.citation.volume16en_US
dc.citation.issue3en_US
dc.citation.spage503en_US
dc.citation.epage512en_US
dc.contributor.department應用化學系zh_TW
dc.contributor.departmentDepartment of Applied Chemistryen_US
dc.identifier.wosnumberWOS:000308555600008-
dc.citation.woscount1-
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