標題: Genotype analysis based on intergenic spacer 1 sequences of Trichosporon asahii collected in Taiwan
作者: Yang, Yun-Liang
Liu, Yi-Wen
Chen, Hui-Ting
Tsai, Moan-Shane
Chu, Wen-Li
Lo, Hsiu-Jung
生物科技學系
分子醫學與生物工程研究所
Department of Biological Science and Technology
Institute of Molecular Medicine and Bioengineering
關鍵字: Trichosporon;intergenic spacer 1;genotypes;IGS1;Trichosporon asahii
公開日期: 1-Nov-2013
摘要: Among 32 Trichosporon asahii isolates collected in four rounds of the Taiwan Surveillance of Antimicrobial Resistance of Yeasts (TSARY) studies, conducted in 1999, 2002, 2006, and 2010, five different intergenic spacer 1 (IGS1) genotypes were detected. Genotype 1 was the most common (43.8%), followed by genotypes 3 (28.1%), 7 (12.5%), 5 (9.4%), and 4 (6.3%). Interestingly, genotype 7 was more prevalent in Taiwan than in other areas (P = 0.01); while we did not find a significant association between IGS1 genotype and susceptibility to antifungal drugs, we did note that the majority of isolates of T. asahii were susceptible to both fluconazole and voriconazole, consistent with previous reports. A higher proportion of isolates (P = 0.05) collected in 2010 (4/12, 33.3%) had high amphotericin B MICs (>= 2 mg/l) than those collected in the previous three TSARYs (1/21, 5%). Hence, the new data of genotypes and drug susceptibilities in the present study may contribute to the epidemiology of T. asahii
URI: http://dx.doi.org/10.3109/13693786.2013.800240
http://hdl.handle.net/11536/22940
ISSN: 1369-3786
DOI: 10.3109/13693786.2013.800240
期刊: MEDICAL MYCOLOGY
Volume: 51
Issue: 8
起始頁: 880
結束頁: 883
Appears in Collections:Articles