標題: | Genotype analysis based on intergenic spacer 1 sequences of Trichosporon asahii collected in Taiwan |
作者: | Yang, Yun-Liang Liu, Yi-Wen Chen, Hui-Ting Tsai, Moan-Shane Chu, Wen-Li Lo, Hsiu-Jung 生物科技學系 分子醫學與生物工程研究所 Department of Biological Science and Technology Institute of Molecular Medicine and Bioengineering |
關鍵字: | Trichosporon;intergenic spacer 1;genotypes;IGS1;Trichosporon asahii |
公開日期: | 1-十一月-2013 |
摘要: | Among 32 Trichosporon asahii isolates collected in four rounds of the Taiwan Surveillance of Antimicrobial Resistance of Yeasts (TSARY) studies, conducted in 1999, 2002, 2006, and 2010, five different intergenic spacer 1 (IGS1) genotypes were detected. Genotype 1 was the most common (43.8%), followed by genotypes 3 (28.1%), 7 (12.5%), 5 (9.4%), and 4 (6.3%). Interestingly, genotype 7 was more prevalent in Taiwan than in other areas (P = 0.01); while we did not find a significant association between IGS1 genotype and susceptibility to antifungal drugs, we did note that the majority of isolates of T. asahii were susceptible to both fluconazole and voriconazole, consistent with previous reports. A higher proportion of isolates (P = 0.05) collected in 2010 (4/12, 33.3%) had high amphotericin B MICs (>= 2 mg/l) than those collected in the previous three TSARYs (1/21, 5%). Hence, the new data of genotypes and drug susceptibilities in the present study may contribute to the epidemiology of T. asahii |
URI: | http://dx.doi.org/10.3109/13693786.2013.800240 http://hdl.handle.net/11536/22940 |
ISSN: | 1369-3786 |
DOI: | 10.3109/13693786.2013.800240 |
期刊: | MEDICAL MYCOLOGY |
Volume: | 51 |
Issue: | 8 |
起始頁: | 880 |
結束頁: | 883 |
顯示於類別: | 期刊論文 |