標題: Rapid Two-Step Synthesis of Benzimidazo[1 \',2 \':1,5]-pyrrolo[2,3-c]isoquinolines by a Three-Component Coupling Reaction
作者: Narhe, Bharat D.
Tsai, Min-Huan
Sun, Chung-Ming
應用化學系
Department of Applied Chemistry
公開日期: 1-Aug-2014
摘要: A two-step, three-component coupling reaction on ionic liquid supported 2-cyanomethylbenzimidazoles, methyl 2-formylbenzoate, and isocyanides under microwave activation is explored. Knoevenagel condensation of 2-cyanomethylbenzimidazole with methyl-2-formylbenzoate in the presence of piperidine catalyst is followed by [4 + 1] cycloaddition with an isocyanide in the next step. Consequent intramolecular delta-lactam formation allows rapid construction of novel aza-pentacycles, benzimidazo [1\',2\':1,5]pyrrolo [2,3-c]isoquinolines.
URI: http://dx.doi.org/10.1021/co500049r
http://hdl.handle.net/11536/25083
ISSN: 2156-8952
DOI: 10.1021/co500049r
期刊: ACS COMBINATORIAL SCIENCE
Volume: 16
Issue: 8
起始頁: 421
結束頁: 427
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