標題: The design of a novel complementary metal oxide semiconductor detection system for biochemical luminescence
作者: Lu, U
Hu, BCP
Shih, YC
Wu, CY
Yang, YS
生物科技學系
電子工程學系及電子研究所
Department of Biological Science and Technology
Department of Electronics Engineering and Institute of Electronics
關鍵字: CMOS;IC design;bioluminescence;enzyme chip;biochemical analysis
公開日期: 15-May-2004
摘要: We designed a complementary metal oxide semiconductor (CMOS) chip with accompanied accessories as a system for the detections and quantifications of biochemical luminescence. This is the first of such instruments that has been reported. The semiconductor chip was manufactured through a 0.25 mum CMOS standard process. A current mirror was designed in integrated circuit (IC) to amplify the signal current that was induced by chemiluminescence. Horseradish peroxidase (HRP)-luminol-H2O2 system was used as an example to constitute a useful platform for coupling to chemiluminescence reactions which produce H2O2. Glucose-glucose oxidase (GOD) reaction was coupled with HRP-luminol-H2O2 reaction to demonstrate the ability of the novel CMOS base instrument for quantifying the biological luminescence of a variety of valuable clinical assays. Our results illustrated that the combination of the specifically designed CMOS IC and commercially available electronic devices established a simple and useful bioanalytical tool. (C) 2003 Elsevier B.V. All rights reserved.
URI: http://dx.doi.org/10.1016/j.bios.2003.11.025
http://hdl.handle.net/11536/26772
ISSN: 0956-5663
DOI: 10.1016/j.bios.2003.11.025
期刊: BIOSENSORS & BIOELECTRONICS
Volume: 19
Issue: 10
起始頁: 1185
結束頁: 1191
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