標題: | A Fully Integrated 8-Channel Closed-Loop Neural-Prosthetic CMOS SoC for Real-Time Epileptic Seizure Control |
作者: | Chen, Wei-Ming Chiueh, Herming Chen, Tsan-Jieh Ho, Chia-Lun Jeng, Chi Ker, Ming-Dou Lin, Chun-Yu Huang, Ya-Chun Chou, Chia-Wei Fan, Tsun-Yuan Cheng, Ming-Seng Hsin, Yue-Loong Liang, Sheng-Fu Wang, Yu-Lin Shaw, Fu-Zen Huang, Yu-Hsing Yang, Chia-Hsiang Wu, Chung-Yu 電機資訊學士班 電子工程學系及電子研究所 生醫電子轉譯研究中心 Undergraduate Honors Program of Electrical Engineering and Computer Science Department of Electronics Engineering and Institute of Electronics Biomedical Electronics Translational Research Center |
關鍵字: | Closed-loop control;epilepsy;neuron modulation;neural prosthesis;system-on-Chip (SoC);wireless power transmission |
公開日期: | 1-Jan-2014 |
摘要: | An 8-channel closed-loop neural-prosthetic SoC is presented for real-time intracranial EEG (iEEG) acquisition, seizure detection, and electrical stimulation in order to suppress epileptic seizures. The SoC is composed of eight energy-efficient analog front-end amplifiers (AFEAs), a 10-b delta-modulated SAR ADC (DMSAR ADC), a configurable bio-signal processor (BSP), and an adaptive high-voltage-tolerant stimulator. A wire-less power-and-data transmission system is also embedded. By leveraging T-connected pseudo-resistors, the high-pass (low-pass) cutoff frequency of the AFEAs can be adjusted from 0.1 to 10 Hz (0.8 to 7 kHz). The noise-efficiency factor (NEF) of the AFEA is 1.77, and the DMSAR ADC achieves an ENOB of 9.57 bits. The BSP extracts the epileptic features from time-domain entropy and frequency spectrum for seizure detection. A constant 30-mu A stimulus current is delivered by closed-loop control. The acquired signals are transmitted with on-off keying (OOK) modulation at 4 Mbps over the MedRadio band for monitoring. A multi-LDO topology is adopted to mitigate the interferences across different power domains. The proposed SoC is fabricated in 0.18-mu m CMOS and occupies 13.47 mm(2). Verified on Long Evans rats, the proposed SoC dissipates 2.8 mW and achieves high detection accuracy 92% within 0.8 s. |
URI: | http://dx.doi.org/10.1109/JSSC.2013.2284346 http://hdl.handle.net/11536/23387 |
ISSN: | 0018-9200 |
DOI: | 10.1109/JSSC.2013.2284346 |
期刊: | IEEE JOURNAL OF SOLID-STATE CIRCUITS |
Volume: | 49 |
Issue: | 1 |
起始頁: | 232 |
結束頁: | 247 |
Appears in Collections: | Articles |
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